Dyspepsia

NICE Clinical guideline [CG184] Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management. Last updated: Oct 2019.

Background Information

Dyspepsia: a group of symptoms arising from the upper GI tract
  • Dyspepsia is not a diagnosis
  • Possible symptoms include: upper abdominal pain / discomfort, heartburn, nausea, vomiting, reflux

There are 2 main types of dyspepsia:
  • Uninvestigated dyspepsia - patients with dyspepsia but have NOT had an endoscopy
  • Functional dyspepsia - also known as non-ulcer dyspepsia, patients with dyspepsia but normal findings on endoscopy (no ulcer, no malignancy, no oesophagitis)

Guidelines

Offer urgent upper gastrointestinal endoscopy (to be performed within 2 weeks) if:
  • Dysphagia alone, or
  • ≥55 y/o with weight loss and any of the following:
    • Upper abdominal pain
    • Reflux
    • Dyspepsia

Consider a suspected cancer pathway referral (for an appointment within 2 weeks) for people with an upper abdominal mass consistent with stomach cancer.

Consider non-urgent direct access upper gastrointestinal endoscopy in people with haematemesis.

Consider non-urgent direct access upper gastrointestinal endoscopy in ≥55 y/o with:
  • Treatment-resistant dyspepsia, or
  • Upper abdominal pain with low haemoglobin levels, or
  • Raised platelet count with any of the following:
    • Nausea,
    • Vomiting,
    • Weight loss,
    • Reflux,
    • Dyspepsia,
    • Upper abdominal pain, or
  • Nausea or vomiting with any of the following:
    • Weight loss.
    • Reflux.
    • Dyspepsia.
    • Upper abdominal pain.

Offer the following to ALL patients:

  • Medication review
  • Lifestyle advice
    • Healthy eating
    • Weight reduction
    • Smoking cessation
    • Reduce alcohol consumption
 
  • Avoid known precipitants associated with their dyspepsia (e.g. smoking, alcohol, coffee, chocolate, fatty food)
  • Raising the head of the bed
  • Eat smaller meals and eat their evening meal 3–4 hours before going to bed
 

1st line: offer one of the following approaches
  • Full-dose PPIProton pump inhibitor for 1 month, or
  • H. pylori test and treat - see this article


2nd line:

  • If symptoms persist → switch to the alternative approach


3rd line:

  • If symptoms still persist → consider H2-receptor antagonist (e.g. ranitidine, famotidine, nizatidine)

If conservative management failed → offer H. pylori test and treat - see this article
Author: Adams Lau
Reviewer:
Last edited: 05/08/25