Newborn Life Support (NLS)

Resuscitation Council UK Newborn resuscitation and support of transition of infants at birth Guidelines

Background Information

APGAR score should be recorded routinely at 1 min and 5 min after birth
 
Component 0 points 1 points 2 points
Appearance Blue / pale completely Peripheral cyanosis only Pink
Pulse (heart rate) 0 <100 >100
Grimace (reflex irritability) No response to stimulation Weak cry when stimulated Strong cry when stimulated
Activity (tone) Floppy Some flexion Active movement
Respiration No breathing Slow / irregular breathing Strong cry

NLS Guidelines

Inflation breaths:
  • To be given if the newborn is not breathing or gasping at birth
  • Aim: open collapsed alveoli and establish functional residual capacity
  • Administration:
    • 2-3 sec of inspiratory time per breath
    • 5 is given back-to-back

Ventilation breaths:
  • To be given if chest movement is present (indicative of patent airway and delivered volume) but heart rate <100 bpm
  • Aim: maintain established lung volume and provide adequate ventilation
  • Administration:
    • ≤1 sec of inspiratory time per breath
    • Regular breaths given 40-60 per min


Most causes of resuscitation are respiratory problems, instead of cardiac problems. More emphasis is put on optimising 'Breathing', if not managed well, any subsequent interventions (including CPR) would be ineffective.

CPR (chest compression to ventilation ratio of 3:1) should only be started if the heart rate is <60 bpm or non-detectable after 30 sec of good quality ventilation 
 

IV adrenaline (1:10,000) 0.2 mL/kg should be given after 30 seconds of effective ventilation and chest compression for 30 sec

Other drugs to consider:
  • Glucose - to reduce the likelihood of hypoglycaemia in prolonged resuscitation
  • Isotonic crystalloid / O -ve blood - for suspected blood loss or shock unresponsive to other resuscitative measures
  • Sodium bicarbonate - for prolonged unresponsive resuscitation with intracardiac acidosis

The following algorithm only applies if the baby is NOT breathing or gasping at birth.
 

Discuss stopping resuscitation if there has been no response after 20 minutes and reversible causes have been excluded.
Author: Adams Lau
Reviewer:
Last edited: 24/08/25