BNF recommends a combination of 2 antiemetic drugs with different mechanisms of action in those with risk factorsRisk factors outlined by the BNF include: - Type and duration of surgery - Anaesthetic used - Female sex - Younger age - Non-smokers - History of post-operative nausea and vomiting / motion sickness - Intraoperative and post-operative use of opioids for post-operative nausea and vomiting.

Drugs used:

• 5HT₃-receptor antagonists (e.g. ondansetron, granisetron)
• Haloperidol and droperidol
• Prochlorperazine
• Dexamethasone
• Cyclizine is licensed for post-operative nausea and vomiting caused by opioids and general anaesthetics 

 
If a drug failed → switch to a different class of antiemetic.

BNF treatment summaries Nausea and labyrinth disorders

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