Prostatitis (Acute)

NICE guideline [NG110] Prostatitis (acute): antimicrobial prescribing. Published: Oct 2018.

Guidelines

Advise:
  • Course of acute prostatitis is several weeks
  • Drink enough fluids to avoid dehydration 

Offer pain relief with paracetamol +/- low-dose weak opioid or ibuprofen.

Obtain a midsteam urine sample for culture and susceptibility, then offer oral antibiotics to all patients with acute prostatitis:
  • 1st line: ciprofloxacin 500mg BD for 14 days / ofloxacin 200mg BD for 14 days
  • 2nd line: trimethoprime 200mg BD for 14 days
  • 3rd line (after discussion with specialist): levofloxacin 500mg OD for 14 days OR co-trimoxazole 960 mg BD for 14 days
Author: Adams Lau
Reviewer:
Last edited: 31/05/25